Fig. 3: Effect of microstructure and composition on release rate. | npj Women's Health

Fig. 3: Effect of microstructure and composition on release rate.

From: Revolutionizing Women’s health: the quest for materials for next-generation, non-hormonal intrauterine devices

Fig. 3

The microstructures of the Cu materials characterized using electron back-scattered diffraction and transmission electron microscopy: coarse grained (CG) Cu (a, b), ultra-fine grained (UFG) Cu (c, d), and UFG Cu-Mg (e, f). Long-term Cu2+ release rate g of CG Cu, UFG Cu and UFG Cu-0.4Mg and Mg2+ release rate of UFG Cu-0.4Mg h immersed in simulated uterine fluid at 37 °C up to 300 days. Reprinted from Effective easing of the side effects of copper intrauterine devices using ultra-fine-grained Cu-0.4Mg alloy, Q. Fan, G et al., 128, 7 pgs, Copyright (2021), with permission from Elsevier.

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