Table 3 Group comparisons of dysautonomia scores according to striatal denervation pattern, sex, and their interaction

Group contrast	SCOPA-AUT	SCOPA-GI	SCOPA-UR	SCOPA-CAR	SCOPA-THER	SCOPA-PUP	SCOPA-SEX
Right vs Symmetric	p = 0.45; β = 0.48	p = 0.99; β = 0.07	p = 0.29; β = −033	p = 0.90; β = 0.00	p = 0.77; β = 0.04	p = 0.58; β = 0.04	p = 0.038; β = −017
Left vs Symmetric	p = 0.045; β = 1.14	p = 0.95; β = −056	p = 0.10; β = −045	p = 0.82; β = −001	p = 0.74; β = 0.04	p = 0.59; β = 0.04	p = 0.001; β = −024
Left vs Right	p = 0.37; β = 0.66	p = 0.96; β = 0.63	p = 0.74; β = 0.11	p = 0.77; β = 0.02	p = 0.99; β = 0.00	p = 0.94; β = 0.00	p = 0.46; β = 0.07
Men vs Women	p = 0.94; β = 0.03	p = 0.98; β = 0.13	p = 0.19; β = 0.33	p = 0.27; β = 0.06	p = 0.001; β = -.37	p = 0.16; β = −010	p < 0.0001; β = 0.51
Sex × Right	p = 0.74; β = 0.37	p = 0.98; β = 0.38	p = 0.84; β = 0.11	p = 0.71; β = 0.04	p = 0.20; β = −031	p = 0.20; β = −020	p = 0.013; β = 0.36
Sex × Left	p = 0.62; β = 0.46	p = 0.99; β = 0.02	p = 0.91; β = 0.05	p = 0.82; β = 0.02	p = 0.06; β = −036	p = 0.17; β = −017	p = .012; β = 0.31
Sex × Sym	p = 0.13; β = 0.95	p = 0.99; β = 0.01	p = 0.006; β = 0.85	p = 0.08; β = 0.12	p = 0.001; β = −044	p = 0.41; β = 0.06	p < 0.0001; β = 0.85

The results of group comparisons ((a)symmetry of striatal denervation, sex) of the n = 759 patients according to different dimensions of dysautonomia (SCOPA-AUT) are represented by p-values and slope β. The terms Left, Right and Symmetric (Sym) refer to the (a)symmetry of striatal denervation, which is predominantly left, right, or symmetric. GLMMs were adjusted for age, laterality, and the total MDS-UPDRS III score. SCOPA-AUT: total dysautonomia score; SCOPA-GI: gastrointestinal dysautonomia score; SCOPA-UR: urinary dysautonomia score; SCOPA-CAR: cardiovascular dysautonomia score; SCOPA-THER: thermoregulatory dysautonomia score; SCOPA-PUP: pupillomotor dysautonomia score; SCOPA-SEX: sexual dysautonomia score. The significant results reported survived FDR correction (in bold).

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