Fig. 2: Two-sample Mendelian randomisation estimates for ERα/ERβ perturbation. | npj Women's Health

Fig. 2: Two-sample Mendelian randomisation estimates for ERα/ERβ perturbation.

From: Menopausal hormone therapy and risk of neuropsychiatric disease: a drug target Mendelian randomisation study

Fig. 2: Two-sample Mendelian randomisation estimates for ERα/ERβ perturbation.

Forest plot showing beta estimates with 95% confidence intervals for genetically proxied perturbation of the oestrogen receptor α (ERα; proxied by bone mineral density [BMD] and sex hormone-binding globulin [SHBG]) and oestrogen receptor β (ERβ; proxied by haemoglobin [HMG]) on Alzheimer’s disease (AD), grey matter volume (GM vol), hippocampal volume (HC vol), white matter hyperintensity volume (WMH vol), depression, and anxiety. For ERβ associations, all estimated signs have been reversed for illustration. Only inverse-variance weighted (IVW) or Wald ratio estimates are shown. Findings significant at a false discovery rate of 5% are marked with an asterisk.

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