Table 2 Biological meaning of differential gene expression in Leydig cells infected with EBOV relative to mock-infected controls
Leydig | Upregulated | Downregulated |
|---|---|---|
Overall | GO:0045087|innate immune response|−25.6 | GO:0098813|nuclear chromosome segregation|−17.7 |
GO:0009615|response to virus|−19.9 | GO:1903047|mitotic cell cycle process|−16.9 | |
GO:0002831|regulation of response to biotic stimulus|−18.3 | GO:0000278|mitotic cell cycle|−16.2 | |
1 dpi | GO:0198738|cell-cell signaling by wnt|−3.7 | No significant terms |
GO:0016055|Wnt signaling pathway|−3.7 | ||
GO:0007517|muscle organ development|−3.6 | ||
2 dpi | No significant terms | R-MMU-1474244|Extracellular matrix organization|−5.7 |
R-MMU-8948216|Collagen chain trimerization|−5.1 | ||
GO:0052695|cellular glucuronidation|−4.4 | ||
4 dpi | GO:0002831|regulation of response to biotic stimulus|−15.1 | GO:0051301|cell division|−18.3 |
GO:0045088|regulation of innate immune response|−13.7 | GO:0098813|nuclear chromosome segregation|−16.7 | |
GO:0009615|response to virus|−13.5 | GO:0000278|mitotic cell cycle|−15.4 | |
7 dpi | GO:0045087|innate immune response|−21.7 | GO:0051000|positive regulation of nitric-oxide synthase activity|−4.1 |
GO:0009615|response to virus|−18.7 | GO:0060485|mesenchyme development|−3.7 | |
GO:0045088|regulation of innate immune response|−15.7 | GO:0099150|regulation of postsynaptic specialization assembly|−3.6 | |
14 dpi | GO:0045087|innate immune response|−23.6 | GO:0042773|ATP synthesis coupled electron transport|−8.7 |
GO:0009615|response to virus|−19.5 | GO:0019646|aerobic electron transport chain|−7.9 | |
GO:0002831|regulation of response to biotic stimulus|−17.9 | GO:0022904|respiratory electron transport chain|−7.8 |
