Fig. 2: ZIKV replication in testes of A129 mice after clearance of systemic infection.
From: CD8+ T cells promote ZIKV clearance and mitigate testicular damage in mice
A Weights of A129 mice infected with ZIKV PRVABC59. Mice were infected intraperitoneally with a target dose of 3log10 PFU. Statistical significance was assessed with two-way ANOVA with Tukey’s multiple comparison correction. Error bars represent standard error of the mean. B Virus detection in the plasma of A129 mice, uninfected, or at 2 dpi or 3 wpi. Lines represent the mean. C Viral titer in the testes at 3 wpi. D Testicular weight of the mice at 3 wpi. Bars show mean. In the experiment related to this figure, 5 mice were used in the PBS group, and 6 in the infection group. Horizontal dotted lines represent the limit of detection. **p < 0.01; ***p < 0.001; ****p < 0.0001.
