Fig. 3: Structure of the 1301B7Fab – EG5.1 SARS-CoV-2 Spike. | npj Viruses

Fig. 3: Structure of the 1301B7Fab – EG5.1 SARS-CoV-2 Spike.

From: Potent neutralization by a RBD antibody with broad specificity for SARS-CoV-2 JN.1 and other variants

Fig. 3: Structure of the 1301B7Fab – EG5.1 SARS-CoV-2 Spike.The alternative text for this image may have been generated using AI.

A Orthogonal views of the Cryo-EM density for the upRBD-1301B7 Fv complex with RBD cyan, 1301B7 heavy and light chains yellow and grey, respectively, and the glycan attached to CDRH3 is shown in magenta. B Ribbon diagram of the final model in the orientations shown in A. (C, D) Orthogonal views of the 1301B7 RBD binding site shown as a green surface on the EG5.1 RBD, with CDR/FR3 residues colored in green. The location of two significant JN.1 mutations L452W and V483del are shown in red. E 1301B7 CDRs/FR3 contact residues shown on the ACE2 binding surface (yellow) of RBD, showing 1301B7 does not bind to the “tip” region of RBD encircled in red on the figure40. F Electron density from the 4.1 Å local-refined map corresponding to a portion of CDRH3 and the N-linked glycan attached to Asn100E. G Molecular interactions between 1301B7 and EG5.1 RBD.

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