Fig. 5: Prophylactic activity of 1301B7 hmAb against SARS-CoV-2 JN.1.
K18 hACE2 transgenic mice were treated i.n. with 1301B7 (2 mg/kg or 20 mg/kg) or isotype control hmAb (20 mg/kg), followed by infection with 105 PFU SARS-CoV-2 JN.1. Body weight (A) and survival (B) were evaluated at the indicated days post-infection (n = 5 mice/group). Mice that lost >25% of their initial body weight were humanely euthanized. Error bars represent standard error of the mean (SEM) for each group of mice. Viral titers in the nasal turbinate (C) and lung (D) at 2 and 4 days p.i. were determined by plaque assay in Vero AT cells (n = 4 mice/group/day). Symbols represent individual mice, bars indicate the mean of virus titers. Dotted lines indicate limit of detection. & indicates virus not detected in any mice from that group. α indicates virus detected in only one mouse for that group. * indicates p < 0.05 as compared to isotype control hmAb as determined by t-test.
