Fig. 2: Weight loss and survival curves of C57BL/6 WT mice inoculated with different doses of WNV-578/10 (blue lines) and WNV-NL20 (red lines) via the intradermal route.
From: In vitro and in vivo characterization of a novel West Nile virus lineage 2 strain
Groups were inoculated at a dose of either 105 (solid lines) or 106 (dashed lines) TCID50/mouse (n = 5 mice per group). A Weight loss post-WNV-578/10 versus WNV-NL20 infection. Error bars represent the SEM. Statistical analyses over day 1–8 pi were done using a 2-way ANOVA (alpha = 0.05). Significant differences are indicated with colored asterisks as follows: WNV-NL20 low dose vs WNV-578/10 low dose (green: 6 dpi *p = 0.0168), WNV-NL20 low dose vs WNV-578/10 high dose (purple: 5dpi **p = 0.0085. 6–8 dpi ****p < 0.0001), WNV-NL20 high dose vs WNV-578/10 high dose (orange: 6–8 dpi ****p < 0.0001), and WNV-578/10 low dose vs WNV-578/10 high dose (blue: 6–8 dpi ****p < 0.0001). B Survival curves of infected mice. Significant differences in survival were observed between WNV-578/10 low dose and WNV-578/10 high dose, WNV-NL20 high dose and WNV-578/10 high dose, and WNV-NL20 low dose and WNV-578/10 high dose, as indicated by the asterisks (p value** = 0.0027) using the Log-rank (Mantel–Cox) test.
