Fig. 1: USUV Af-3-NL infected mice show rapid disease progression and lethality at doses as low as 500 pfu.
From: Dose and strain dependent lethality of Usutu virus in an Ifnar−/− mouse model
a Ifnar−/− mice were inoculated subcutaneously with USUV Af-3-NL, with doses ranging from 5 × 104 to 5 × 102 pfu/mouse (n = 8) or with DMEM (n = 3). Animals were euthanized when they reached a humane endpoint. b Survival rates for each of the experimental groups. Statistical analysis was performed using the log-rank (Mantel-Cox) test. c Daily weight loss measured as a percentage of initial weight for each of the experimental groups showing mean ± SEM. Statistical analysis was performed using a one-way ANOVA for each time point. *P < 0.05, **P < 0.01, ****P < 0.0001.
