Table 1 Summary of clinical signs and gross lesions observed in young (Y) and old (O) turkeys inoculated intramuscularly at 1 day and 6 weeks of age, respectively, with either aquatic bird bornavirus 1 (virus-inoculated, VI) or carrier only (control, CO). Clinical signs and gross lesions are tallied from inoculation to the end of the trial (12 weeks post-inoculation (wpi))

From: Pathogenesis of aquatic bird bornavirus 1 in turkeys of different age

  

NSa

CV

MSK

PI

M/N

MISC

Age cohort

Time window

VI

CO

VI

CO

VI

CO

VI

CO

VI

CO

VI

CO

Young

1 wpi

-

-

DCMb (2)c

-

-

-

PD (4)

-

-

SO (2)

-

-

4 wpi

-

-

DCM (9), AS (1), PE (1)

DCM (5), DP (3), AS (1)

-

ALD (1)

PD (3)

PD (2)

LBC (3)

-

-

UH (1), GIH (1)

8 wpi

-

-

DCM (1), DP (1), AS (1)

DCM (3), RPH (1)

SC (1)

ALD (4)

BU (1)

-

LBC (1)

-

-

-

12 wpi

ATX (6), REC (3)

-

DCM (5), PE (3), PC (2), HP (1)

-

ALD (1), SC (1)

ALD (1)

BU (7),

BU (2)

-

-

-

-

Old

1 wpi

-

-

DCM (1), RPH (1)

-

CT (3)

ALD (4), TD (1),

FP (1)

-

RU (1)

RU (1)

-

-

4 wpi

-

-

DCM (1), DP (1), AS (1), PE (1)

-

TD (1)

-

FP (1)

-

-

-

-

-

8 wpi

-

-

DCM (1)

AA (1), DCM (1)

SP (1)

ALD (4), TD (1), CD (2), SC (1)

BU (1)

FP (1), FX (1), BU (3), PN (1)

-

-

-

-

12 wpi

-

-

DCM (1), AS (1)

-

-

ALD (1)

BU (3), PD (1), PN (1)

BU (1)

-

-

HU (1)

-

  1. aIndicates categorization by either system or disease process: nervous system (NS), cardiovascular system (CV), musculoskeletal system (MSK), physical injury (PI), metabolic/nutritional (M/N), miscellaneous (MISC).
  2. bIndicates clinical sign or lesion: ataxia/inability to stand (ATX), sternal recumbency (REC), dyspnea (DP), dilated cardiomyopathy (DCM), pulmonary edema (PE), ascites (AS), pulmonary congestion (PC), hydropericardium (HP), retroperitoneal hemorrhage (RPH), aortic aneurysm (AA), angular limb deformity (ALD), chondrodystrophy/perosis) (CD), curled toes (CT), tibial dyschondroplasia (TD), scoliosis (SC), fracture (FX), spondylosis (SP), bursitis (BU), pressure necrosis (PN), feather pecked (FP), pododermatitis (PD), umbilical hernia (UH), starve out (SO), low body condition (LBC), runt (RU), not assessed (NA), gastrointestinal hemorrhage (GIH), hydroureter (HU).
  3. cThe number in parenthesis indicates the number of affected birds for that clinical sign/lesion for that time point.