Fig. 3: Genomic organization and function of arthropod- and vertebrate-associated members (arbo-JMV).
From: Strange relatives: the enigmatic arbo-jingmenviruses and orthoflaviviruses
A Genomic organization of arbo-JMV. The coding region and translational direction are indicated by means of a different colour for each segment. The virus strain is indicated in the bracket. Segments 1 and 3 in all arbo-JMV code one protein, while segments 2 and 4 code for either one or two proteins depending on the virus strain. B Jingmen tick virus (JMTV), Alongshan virus (ALSV) and Tick-borne encephalitis virus (TBEV) NS3 helicase structural models. i JMTV NS3 helicase structure predicted by Alphafold. ii JMTV NS3 helicase structure superimposed onto experimentally determined ALSV NS3 helicase structure (PDB code: 6M40)49. iii JMTV NS3 helicase structure superimposed onto experimentally determined TBEV NS3 helicase (PDB code: 7OJ4)51. The functional domains are shown in ii and iii. C JMTV, ALSV and dengue virus methyltransferase (MTase) structural models. i JMTV MTase structure predicted by Alphafold. ii JMTV MTase structure superimpositioned onto experimentally determined ALSV MTase structure (PDB code: 8GY9)55. iii JMTV MTase structure superimpositioned onto experimentally determined Dengue virus MTase structure (PDB code: 3P97)83. The position of S-adenosyl-l-methionine (SAM) methyl donor during viral cap formation is shown in ii and iii.
