Fig. 5: In vivo evaluation of LGTVDNA+L–2000 from passage 6 and LGTVLab in C57BL/6J mice.
A Schematic illustration of study layout showing mice groups, infection plan and sampling time points. Mice sera from all animals (n = 6) or half of the animals (n = 3) in each group were collected at different time points. B Relative body weights measured at different time points and presented as percentage of initial body weight of each mouse. C Viremia presented as mean RNA copies per mL at indicated time points. D Levels of anti-TBEV IgG antibodies in mice sera at 21 dpi. Bars represent the standard deviations of mean IgG levels per group. A threshold for positive samples was set to 126 Vienna Units per mL (VIEU/mL) as per manufacturer’s instructions. Significance was calculated in comparison to the control mice (*p < 0.05, ****p < 0.001), and error bars represent SEM.
