Fig. 4: Identification of putative epitopes recognized by AGP-R mAbs. | npj Viruses

Fig. 4: Identification of putative epitopes recognized by AGP-R mAbs.

From: Discovery of potent cross-neutralizing antibodies against Marburg and Ravn viruses with therapeutic potential

Fig. 4

a Amino acid substitutions in MARV GP identified in escape mutants selected by each mAb are shown. b A schematic of MARV GP domains: the GP1 subunit comprises the receptor binding domain (RBD), glycan cap, and mucin-like domain (MLD); the GP2 subunit includes the internal fusion loop (IFL), heptad repeats 1 and 2 (HR1 and HR2), the transmembrane domain (TM), and the cytoplasmic tail. Amino acid substitutions identified in escape mutants of R1-, R4-, and R11-group mAbs are indicated in red, green, and blue, respectively. c Amino acid residues associated with putative mAb epitopes are mapped on the GP trimer structure (PDB ID: 6BP2). Structural data are unavailable for amino acid positions 1–32, 181–468, 499–504, and 630–681.

Back to article page