Fig. 4: LASV selectively induces CD80 surface upregulation in infected bmDCs. | npj Viruses

Fig. 4: LASV selectively induces CD80 surface upregulation in infected bmDCs.

From: Lassa virus circumvents macrophage and dendritic cell antiviral defences in its natural reservoir, the Natal multimammate mouse (Mastomys natalensis)

Fig. 4: LASV selectively induces CD80 surface upregulation in infected bmDCs.The alternative text for this image may have been generated using AI.

Flow cytometric quantification of the percentage of mature cells (MHC-II⁺/CD80high; a,c) and CD80 mean fluorescence intensity (MFI; b,d) in bmMΦs (a,b) and bmDCs; (c,d) from NMM. Cells were either mock-infected, stimulated with LPS, Poly I:C, SeV, or infected with LASV-ZsGreen (MOI = 2) and measured at 0, 1, 2, 3, and 4 DPI. In LASV-infected groups, ZsG⁺ cells represent productively-infected cells (expressing viral ZsGreen), while ZsG⁻ cells correspond to uninfected bystander cells from the same cultures. Data shown represent cells from four animals. Lines indicate arithmetical means. Statistical analysis was performed using two-way ANOVAs with Dunnett’s post-hoc tests. **p < 0.01 & *p < 0.05.

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