Fig. 6: Melatonin receptor signaling sets the phase of the hippocampal pCREB “rhythm”. | npj Biological Timing and Sleep

Fig. 6: Melatonin receptor signaling sets the phase of the hippocampal pCREB “rhythm”.

From: Melatonin’s role in the timing of sleep onset is conserved in nocturnal mice

Fig. 6

a The diurnal pCREB rhythm is phase advanced in MT1/2−/− compared to MT1/2+/+ mice. For better visualization of the rhythms and their phase relationship, the 24-h data points are double plotted. b representative time series of pCREB signal (green) in the dorsal hippocampus of MT1/2−/− and MT1/2+/+ mice. Cosinor analysis was applied to the 24-h dataset.

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