Fig. 1: IDH1 MT are sensitive to VPA in vitro and in vivo.
From: Valproic acid targets IDH1 mutants through alteration of lipid metabolism
A–C Dose–response curve of IDH MT (3 cell lines) and IDH WT (2 cell lines) treated with VPA (A), Panobinostat (B), and Belinostat (C) for 1 week. D D-2HG content in the human primary WT & MT cell lines. E Kaplan–Meier survival curve for mice treated with either saline or VPA (300 mg/kg, twice daily) implanted with BT142. Non-linear regression, one-way ANOVA, ****P value<0.0001; ***P value<0.001; Error bars ± SD.
