Fig. 2: VPA improves survival of mice in a murine isogenic IDH MT model. | npj Metabolic Health and Disease

Fig. 2: VPA improves survival of mice in a murine isogenic IDH MT model.

From: Valproic acid targets IDH1 mutants through alteration of lipid metabolism

Fig. 2

A and B Dose–response curves of mIDH1MT and mIDH1WT treated with VPA (D) or Belinostat (E) for 5 days. C D-2HG content in murine mIDH1WT and mIDH1MT cell lines NPAC54B and NPAIC1. D and E Kaplan–Meier survival curve for mice with NPAC54B or NPAIC1 xenograft treated with either saline or VPA (300 mg/kg, twice daily. Non-linear regression, T-test, ****P value<0.0001; ***P value<0.001; Error bars ± SD.

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