Fig. 3: Altered diurnal rhythms in fatty acid and cholesterol metabolism in the liver of THRBKO mice. | npj Metabolic Health and Disease

Fig. 3: Altered diurnal rhythms in fatty acid and cholesterol metabolism in the liver of THRBKO mice.

From: Thyroid hormone receptor beta (THRB) dependent regulation of diurnal hepatic lipid metabolism in adult male mice

Fig. 3

A Diurnal profiling of liver transcripts (using CircaCompare) was performed, and numbers of differentially rhythmic genes (DRGs) are represented as UpSet plot. B Enrichment analysis of the top-5 processes for each DRG class (amplitude, phase, mesor) are shown. C, D Manual curation of lipid metabolism-associated DRGs for mesor was performed and shown as heat maps. Chord plots show gene names and associated biological processes. E Genes associated with the biological processes were averaged and plotted across 24 h and diurnal analysis was performed using CircaCompare. BAF bile acid formation, CHO cholesterol metabolism, FAO fatty acid oxidation, FAS fatty acid synthesis, LPC lysophosphatidylcholine, PI3K phosphoinositide 3-kinase, PI and PS phosphatidyl and phosphatidylserine metabolism. N = 3 independent samples per time point and condition. R = presence of rhythmicity. NR = absence of rhythmicity.

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