Fig. 4: Loss of THRB alters liver lipidome rhythms with increased cholesterol, fatty acids, di- and triglycerides. | npj Metabolic Health and Disease

Fig. 4: Loss of THRB alters liver lipidome rhythms with increased cholesterol, fatty acids, di- and triglycerides.

From: Thyroid hormone receptor beta (THRB) dependent regulation of diurnal hepatic lipid metabolism in adult male mice

Fig. 4

A Rhythmic lipids after diurnal profiling (using JTK_cycle, Metacycle, and CircaN) are shown in a Venn diagram for THRBWT (grey) and THRBKO livers (blue). B Distribution of lipid classes identified as rhythmic in THRBWT (left) or THRBKO livers. C Rose plot depicting acrophase differences of robustly rhythmic lipids between genotypes. D UpSet plot representing numbers of lipids with specific rhythm parameter changes (mesor, amplitude, phase) identified by CircaCompare. E Examples of lipids with alterations in specific rhythm parameters. N = 3 independent samples per time point and condition.

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