Fig. 7: SMRT expression negatively associated with inflammation in human autoimmune diseases. | npj Metabolic Health and Disease

Fig. 7: SMRT expression negatively associated with inflammation in human autoimmune diseases.

From: SMRT-depleted conventional DCs maintain inflammation despite lower glycolysis via mTOR signalling and succinate oxidation

Fig. 7: SMRT expression negatively associated with inflammation in human autoimmune diseases.

A Box plots within Violin showing the normalized expression of SMRT and IL-1β, glycolytic genes—GAPDH, PKM and LDHA, and glutamine transporter SLC1A5 (median levels and distribution) from ileal RNA-seq datasets, healthy (n = 32) and Crohn’s disease (n = 36) samples. B Representative Colonoscopy images of IBS and UC samples. Immunofluorescence microscopy images showing relative intensities of SMRT in IBS (n = 3) vs UC (n = 5). C Immunofluorescence microscopy images showing relative intensities of SMRT, and glycolytic proteins - GAPDH and PKM2 in IBS (n = 3) vs UC (n = 5). D Dot plots demonstrating the gating strategy to identify CD3+CD4+ T cells and cDC1 DCs (CD11c+HLADR+CD141+) from PBMCs. Box plots depicting the MFI levels of TBET and SMRT in Healthy (n = 11) vs RA (n = 16). E Scatter plot demonstrating the negative correlation between SMRT and TBET in Healthy (n = 11) vs RA (n = 16). *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001 and ****p ≤ 0.0001. p-value has been calculated using two tailed student’s unpaired t-tests. Error bars represent SEM.

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