Fig. 4: Cartoon illustrating how increased insulin chain splitting during transport to and/or in ISF will result in increased plasma insulin/insulin resistance.
From: Chain splitting of insulin: an underlying mechanism of insulin resistance?
The left panel represents the insulin concentration gradient from published data18 in healthy individuals. The middle panel illustrates how increased chain splitting will result in a larger gradient according to our hypothesis, leading to compensatory insulin secretion, plasma hyperinsulinaemia and thus insulin resistance as shown in the right panel.
