Fig. 2: Oxygen tension and hypoxia in the intestine are essential for regulating the equilibrium between oxidative metabolism and glycolysis, affecting nutritional absorption, barrier integrity, and immunological function.
From: Mechanisms and implications of the gut microbial modulation of intestinal metabolic processes
Optimal oxygen levels facilitate an anaerobic environment conducive to beneficial gut bacteria, while hypoxia-induced signaling pathways regulate crucial protective genes necessary for gut homeostasis. This figure summarizes the major metabolic, molecular, cellular, and physiological activities at the gut that are impacted by luminal oxygen level.
