Fig. 2: Metabolic age distributions in individuals with prostate cancer and metabolic dysfunction-associated steatotic liver disease (MASLD).

Samples from individuals with prostate cancer are overlaid on those from a male reference population in (A) (orange and blue, respectively), and histograms of the differences between metabolic and chronological age (metabolic distortion) for these groups are shown in (B). C MASLD samples overlaid on a reference population, with subtype A in red and subtypes B + C in orange, while D presents histograms of metabolic distortion for these MASLD subtypes alongside a matched reference population (orange and blue, respectively). Differences in metabolic distortion between MASLD subtype A and subtypes B + C are shown in (E). Mean and standard deviation values of metabolic distortion for individuals with prostate cancer and MASLD (combined subtypes A + B + C) are indicated in orange; corresponding values for their respective reference populations are indicated in blue. p-Values from Kolmogorov–Smirnov tests assessing distribution differences are shown in black.