Table 1 Endogenous expression of UCPs in human cancers
UCP1 | CANCER TYPE | REGULATION | METHODS OF DETECTION | ASSAY ON MITOCHONDRIAL/UNCOUPLED RESPIRATION | REFERENCE |
|---|---|---|---|---|---|
Prostate cancer | Upregulated In clinical specimen | IHC | no | ||
Triple-negative breast cancer | Downregulated in bt549 cell line and specimen | WB and IHC | no | ||
Non-small cell lung cancer (NSCLC - alveolar cells) | Upregulated in specimen | IHC | No | ||
Breast cancer | Downregulated in clinical specimen | IHC | no | ||
Colorectal carcinoma | Upregulated In specimen | IHC | no | ||
Myeloid-derived suppressor cells | Downregulated | WB | no | ||
ccRCC | Downregulated | WB and IHC | no | ||
Breast cancer | Upregulated in ER positive and differentiated breast tumors | IHC | Yes increase in proton leak in vitro | ||
Breast cancer | Expression positively associated with prognostic status and RFS/OS | IHC | thermal tomography; higher expression in patients with q-r curves at 30 °–45 ° | ||
UCP2 | Cancer Cell lines | Upregulated in resistant vs sensitive | WB | Yes (increase in OCR together with decrease in MMP) in vitro | |
Colon cancer | upregulated | IHC and WB | no | ||
Colon cancer | upregulated | IHC WB | no | ||
Breast Cancer | Upregulated in grade 3 vs grade 1 | IHC and WB | Yes in primary tumor cells Higher MMP in grade 3 vs grade1 cells in vitro | ||
Breast ovarian, bladder, esophageal, testicular, kidney, colorectal, lung, pancreas prostate leukemia | Upregulated | Microarray | In vitro overexpression - decrease in MMP | ||
Head and neck, skin, prostate, and pancreatic tumor samples | Upregulated vs surrounding normal tissues | WB | no | ||
Patient-derived ovarian cancer stem cells | Upregulated vs differentiated | WB | Yes (higher MMP) | ||
clear cell renal cell carcinoma (ccRCC) | Downregulated In patient tumor samples vs surrounding normal tissues | WB | Yes on isolated mitochondria from ccRCC samples (higher MMP in tumor samples) | ||
uterine cervical cancer | Expression positively related with sensitivity to neo adjuvant chemotherapy and negatively with survival | IHC | No | ||
Ovarian carcinoma | Expression positively related with sensitivity to platinum and negatively with survival | IHC | No | ||
Melanoma | Upregulated in patients with high T cell anti-tumor responses | Single cell RNAseq | no | ||
Colorectal cancer | Upregulated vs normal mucosa samples | WB | In vitro UCP2 KO in tumors show increase in glycolysis with no effect on OXPHOS or proton leak | ||
Gallbladder cancer (GBC) | Upregulated vs surrounding normal tissues | WB | In vitro Inhibition on GBC results in increase in MMP | ||
Uterine cervical cancer | Expression positively related with clinical stage and lymph node metastasis | IHC | no | ||
Breast cancer | Expression positively associated with prognostic status and RFS/OS | IHC | thermal tomography; no change between q-r curves in patients | ||
UCP3 | NSCLC | Upregulated In specimen | IHC | no | |
ccRCC | Upregulated | WB | no | ||
ccRCC | Upregulated In patient tumor samples vs surrounding normal tissues (only the long isoform UCP3L) | WB | Yes on isolated mitochondria from ccRCC samples(higher MMP in tumor samples) |
