Table 2 Impact of AQP7 deficiency on body weight and metabolic parameters after high glucose diet in mouse
From: AQP7 deficiency drives adipose tissue remodeling and disrupts homeostasis
High-glucose diet (8 weeks) | ||||
|---|---|---|---|---|
Aqp7+/+ | Aqp7+/+ | Aqp7+/− | Aqp7−/− | |
Body weigh after diet (g) | 22.7 ± 0.5 | 25.1 ± 0.9*** | 26.8 ± 1.0***$$$ | 26.7 ± 0.7***$$ |
Body weight gain (%) | 19.6 ± 3.9 | 30.63 ± 4.2*** | 33.6 ± 8.2*** | 39.13 ± 3.7***$$ |
Kcal intake (Kcal/day) | 7.23 ± 0.79 | 15.20 ± 1.96 | 15.32 ± 2.55 | 15.68 ± 0.83 |
Kcal food intake (Kcal/day) | 7.23 ± 0.79 | 5.45 ± 1.44 | 5.87 ± 2.22 | 5.77 ± 0.89 |
Kcal glucose intake (Kcal/day) | 0.00 ± 0.00 | 9.75 ± 0.95 | 9.45 ± 0.73 | 9.90 ± 0.42 |
Metabolic parameters (plasma) | ||||
Glucose (mg/dL) | 150.4 ± 4.0 | 158.1 ± 3.0 | 184.1 ± 13.6***$$$ | 189.3 ± 11.9***$$$ |
Insulin (ng/mL) | 0.55 ± 0.13 | 0.78 ± 0.12 | 1.05 ± 0.11** | 1.78 ± 0.46***$$$### |
Glycerol (nM) | 0.28 ± 0.02 | 0.36 ± 0.03*** | 0.30 ± 0.04$ | 0.26 ± 0.03$$$ |
Free fatty acid (nM) | 0.83 ± 0.11 | 0.89 ± 0.15 | 1.05 ± 0.11* | 1.14 ± 0.20**$$ |
BUN (mg/dl) | 24.2 ± 2.1 | 24.73 ± 1.6 | 26.3 ± 2.8 | 23.7 ± 1.3 |
Adipose tissue parameters | ||||
Whole-body fat (g) | 1.36 ± 0.05 | 3.33 ± 0.77*** | 4.28 ± 0.40***$$ | 4.34 ± 0.57***$$ |
Visceral fat area (cm2) | 0.14 ± 0.03 | 0.47 ± 0.10*** | 0.72 ± 0.10***$$$ | 0.75 ± 0.09***$$$ |
Dorsal muscle density | 0.92 ± 0.02 | 0.92 ± 0.03 | 0.88 ± 0.04 | 0.84 ± 0.03***$$$ |
Liver density | 0.94 ± 0.02 | 0.94 ± 0.02 | 0.87 ± 0.04***$$$ | 0.86 ± 0.04***$$$ |
Adipocyte size (μm2) | 1187 ± 635 | 3586 ± 1299*** | 5787 ± 1471***$$$ | 6137 ± 1717***$$$# |
Adipocyte number | 742 ± 156 | 547 ± 113** | 416 ± 45*** | 382 ± 60***$ |
