Fig. 3: Feeding HFD during lactation augments nephron number during the final days of nephrogenesis and can rescue a programmed nephron deficit.
From: Maternal nutrition can rapidly rescue a nephron deficit in low birthweight offspring
Body weight in ND (n = 8 litters), N/HFD (n = 8 litters), HFD (n = 7 litters), LPD (n = 9 litters) and LP/HFD (n = 8 litters) at P2, P7, P14 and P21 (a). Each point in a represents the average body weight for each litter (sexes combined following no detectable sex difference), with whiskers extending to the smallest and largest value, and the box extending from the 25th to 75th percentiles, with a solid line indicating the median. Kidney weight (b), total number of glomeruli per kidney (Nglom) (c), total number of glomeruli per kidney per gram of body weight (d) and glomerular volume (e) in ND, N/HFD, HFD, LPD and LP/HFD at P21. Each point in the box and whiskers plot in k–m represents an individual male or female from a single litter, with whiskers extending to the smallest and largest value, and the box extending from the 25th to 75th percentiles, with a solid line indicating the median where n = 7–9 litters (HFD: n = 14 from 7 litters, ND, N/HFD and LP/HFD: n = 16 from 8 litters, LPD: n = 18 from 9 litters. Different letters indicate statistically significant differences (p < 0.05).
