Fig. 5: Prolonged nephron induction contributes to augmented nephron endowment.
From: Maternal nutrition can rapidly rescue a nephron deficit in low birthweight offspring
a Representative images of the nephrogenic zone in ND (i), HFD (ii), LPD (iii) and LP-HFD (iv) offspring at P2, and ND (v), HFD (vi), LPD (vii) and LP-HFD (viii) at P3. Scale bars = 50 µm. Representative self-renewing SIX2+ (pink) cells outlined in white, ECAD+ (green) ureteric tips outlined in black. Representative committed SIX2+ structures are indicated with a dashed outline. b The number of self-renewing SIX2+ structures per tip in ND, HFD, LPD and LP-HFD offspring at P2 and P3 (c). The number of differentiated SIX2+ structures per tip in ND, HFD, LPD and LP-HFD offspring at P2 and P3. Points in (b) and (c) represent average values from >25 tips for one sample, from 5-6 litters per diet per timepoint. *p < 0.05, **p < 0.01. Only significant differences with each time point and within each diet across time are shown.
