Table 1 Baseline population characteristics by eGFR categoriesa

From: Different cardiovascular risks associated with elevated creatinine-based eGFR and cystatin C-based eGFR

 

eGFRcr

 

eGFRcyc

Low

Normal

High

P value

Low

Normal

High

P value

N

18,575

334,919

18,566

  

18,573

334,932

18,555

 

Age, years

55.9 (8.0)

55.7 (8.0)

55.2 (8.0)

<0.001

 

55.9 (8.0)

55.7 (8.0)

55.3 (8.0)

<0.001

Male, No. (%)

8265 (44.5)

149,049 (44.5)

8263 (44.5)

0.999

 

8266 (44.5)

149,055 (44.5)

8256 (44.5)

0.999

White, No. (%)

17,709 (95.3)

320,168 (95.6)

15,533 (83.7)

<0.001

 

17,480 (94.1)

318,573 (95.1)

17,357 (93.5)

<0.001

Body mass index, kg/m2

27.7 (4.3)

27.1 (4.5)

27.2 (5.3)

<0.001

 

30.4 (5.9)

27.1 (4.4)

25.2 (3.5)

<0.001

Systolic blood pressure, mmHg

136.6 (18.0)

137.1 (18.2)

138.3 (18.5)

<0.001

 

138.4 (18.1)

137.1 (18.2)

136.4 (18.5)

<0.001

Diastolic blood pressure, mmHg

82.3 (10.0)

82.2 (9.9)

82.5 (10.1)

<0.001

 

84.2 (10.2)

82.2 (9.9)

80.9 (9.8)

<0.001

Smoking status, No. (%)

   

<0.001

    

<0.001

Never

11,097 (59.7)

189,458 (56.6)

9460 (51.0)

  

9110 (49.0)

190,085 (56.8)

10,820 (58.3)

 

Former

6189 (33.3)

112,000 (33.4)

5927 (31.9)

  

5530 (29.8)

111,832 (33.4)

6754 (36.4)

 

Current

1232 (6.6)

32,421 (9.7)

3112 (16.8)

  

3850 (20.7)

31,977 (9.5)

938 (5.1)

 

Antihypertensive drug use, No. (%)

3419 (18.5)

50,138 (15.1)

3626 (19.8)

<0.001

 

4582 (24.9)

50,195 (15.1)

2406 (13.0)

<0.001

Cholesterol-lowering drug use, No. (%)

2514 (13.6)

38,117 (11.4)

2585 (14.1)

<0.001

 

2836 (15.4)

38,196 (11.5)

2184 (11.8)

<0.001

History of diabetes, No. (%)

557 (3.2)

12,629 (4.0)

1890 (10.8)

<0.001

 

1187 (6.7)

12,937 (4.1)

952 (5.4)

<0.001

Total cholesterol, mmol/L

5.7 (1.1)

5.8 (1.1)

5.7 (1.2)

<0.001

 

5.7 (1.2)

5.8 (1.1)

5.7 (1.1)

<0.001

High-density lipoprotein cholesterol, mmol/L

1.4 (0.4)

1.5 (0.4)

1.5 (0.4)

<0.001

 

1.3 (0.3)

1.5 (0.4)

1.6 (0.4)

<0.001

Triglycerides, mmol/L

1.8 (1.0)

1.7 (1.0)

1.8 (1.2)

<0.001

 

2.1 (1.1)

1.7 (1.0)

1.4 (0.9)

<0.001

C-reactive protein, mg/L

2.4 (3.6)

2.4 (3.9)

2.9 (4.8)

<0.001

 

4.1 (5.4)

2.3 (3.9)

1.6 (3.2)

<0.001

Creatinine, mg/dL

1.0 (0.1)

0.8 (0.1)

0.6 (0.1)

<0.001

 

0.9 (0.2)

0.8 (0.1)

0.7 (0.1)

<0.001

Cystatin C, mg/L

1.0 (0.1)

0.9 (0.1)

0.8 (0.1)

<0.001

 

1.1 (0.1)

0.9 (0.1)

0.7 (0.1)

<0.001

eGFRcr, mL/min/1.73 m2

68.1 (4.7)

92.4 (9.9)

108.3 (7.6)

<0.001

 

83.7 (12.4)

92 (11.3)

99.7 (9.7)

<0.001

eGFRcyc, mL/min/1.73 m2

82.1 (13.7)

91.8 (13.9)

101.3 (12.4)

<0.001

 

66.9 (5.4)

92.0 (12.6)

113.0 (7.0)

<0.001

  1. aValues are presented as means (SD) or proportions.
  2. eGFR estimated glomerular filtration rate, eGFRcr eGFR based on creatinine, eGFRcys eGFR based on cystatin C.
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