Fig. 1: Cost-effectiveness acceptability curve across WTP thresholds.
From: Economic modeling of polygenic risk prediction of coronary artery disease in childhood
The cost-effectiveness acceptability curve (CEAC) illustrates the probability that the PRS-guided CAD prevention program is cost-effective across a range of willingness to pay (WTP) thresholds. The program achieves a probability of cost-effectiveness exceeding 95% at a WTP of approximately $50,000 per quality-adjusted life year (QALY) and reaches near-certainty above $60,000 per QALY. The vertical purple line marks the calculated ICER of $5188 per QALY, demonstrating that the intervention is highly cost-effective, even at conservative WTP thresholds widely used in health policy decision-making.
