Table 5 Probabilistic sensitivity analysis (PSA) results based on 1000 Monte Carlo simulations

From: Economic modeling of polygenic risk prediction of coronary artery disease in childhood

Outcome

Mean

95% Confidence interval

ROI

3647%

2781–4672%

CAD cases prevented

72 cases

58–86 cases

QALYs gained

959 QALYs

756–1156 QALYs

Probability is cost-effective at $50,000/QALY

>99%

–

  1. Mean values and 95% confidence intervals (CI) are shown for return on investment (ROI), number of coronary artery disease (CAD) cases prevented, total quality-adjusted life years (QALYs) gained, and the probability of cost-effectiveness at a willingness-to-pay threshold of $50,000 per QALY.
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