Fig. 4: Mechanism overview.

a Schematic of the proposed mechanism of action. Native and substrate proteins coat a larger section of the interior surface of the capillary causing macroscale changes to its hydrophobicity compared to misfolded protein. b Capillary distances traveled by buffer solution in the capillaries pre-treated with negative (native), positive (misfolded), or buffer (no protein) samples. Eight and six technical replicates for PrP and alpha syn respectively (error bars show stdev). c Example of contact angle measurements of glass slides pre-treated with misfolded PrP vs native PrP. The dashed line denotes the glass surface, distinguishing the droplet from the reflection of the droplet. d Contact angle measurements for glass slides pre-treated with PrP and α-syn.