Table 4 Median biomarker concentrations in uninfected and infected neonatal saliva

From: Ultrasensitive detection of six sepsis-associated proteins in neonatal saliva

Biomarker

Uninfected median and [IQR] (pg/mL), n = 22

Infected median and [IQR] (pg/mL), n = 18

Log hazards ratio

Std. error

z-value

p (two-tailed)

Power (1−β)

CXCL6

170. [111.–536.]

594 [189.–9870]

−1.71

0.491

−4.18

2.98e−5

0.987

CCL20

33.5 [20.9–92.6]

188 [37.1–3048]

−1.36

0.386

−3.52

4.28e−4

0.941

SAA1

762 [774.–1814]

2470 [774.–27179]

−1.33

0.399

−3.33

8.58e−4

0.915

CXCL12

42.0 [65.1–99.8]

42.0 [65.1–74.3]

−0.013

0.332

−0.039

0.970

4.62e−3

LBP

767 [450.–3.48e3]

2230 [450.–1.39e4]

−0.631

0.336

−1.88

0.060

0.468

Resistin

30.9 [19.8–512.]

240. [19.8–7.88e3]

−0.313

0.330

−0.950

0.343

0.154

Total protein (mg/mL)

13.7 [13.4–14.8]

13.6 [12.6–15.8]

−0.218

0.329

−0.66

0.508

0.093

  1. Each sample measurement is the mean of duplicate biomarker measurements fit to the assay calibration curves in Fig. 2, multiplied by the dilution factor. Medians and interquartile ranges (IQR) are reported for uninfected (n = 22) and infected (n = 18) neonates. Significance level is reported as the p-value of the interval-censored parametric proportional hazard model, which accounts for data censoring at the LOD or ULOQ.