Fig. 7: Thermodynamic state functions for fibrin clot contraction.

Changes in the free energy \(\Delta E\) profiled as functions of contraction time \(t\) (the bottom \(x\)-axis) and clot volume \(V\) (the upper \(x\)-axis) for different values of (a): serum viscosity \(\eta\), (b): filopodia extension-retraction speed \(v\), (c): filopodia traction force \(f\), and (d): filopodia length \(l\). The insets show the changes in the internal energy \(\Delta U\) (dashed lines), and entropy \(T\Delta S\) (solid lines) profiled as functions of \(t\) (the bottom \(x\)-axis) and \(V\) (the upper \(x\)-axis). In each (a–d), the time and volume profiles obtained for the experimental reference parameters (see Fig. 4a and Supplementary Table 1), is shown in black color.