Fig. 8: Comparison of final fibrin clot structures. | npj Biological Physics and Mechanics

Fig. 8: Comparison of final fibrin clot structures.

From: Exploring effects of platelet contractility on the kinetics, thermodynamics, and mechanisms of fibrin clot contraction

Fig. 8

Shown are the snapshots of the central 10 µm square cross-section of the fibrin clot after \(t=\) 15 min of clot contraction obtained from the ClotDynaMo simulations (a): for experimental reference parameters (see Supplementary Table 1 and Fig. 4a), and for the following cases: (b): slow filopodia extension-retraction speed \(v=\) 0.01 µm/s showing the fibrin network formed by less bent and less stretched fibrin fibers forming a much smaller number of cohesive inter-fiber bonds; (c): stronger filopodia traction force \(f=\) 1.5 nN displaying no substantial differences in the final clot structure; and (d): longer filopodia length \(l=\) 5 µm showing the fibrin network with a large number of inter-fiber bonds and with great extent of platelet association.

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