Table 2 Thermodynamics of platelet-driven fibrin clot shrinkage

From: Exploring effects of platelet contractility on the kinetics, thermodynamics, and mechanisms of fibrin clot contraction

Parameter

Value

\(\Delta E\), kJ/mol

\(\Delta U\), kJ/mol

\(T\Delta S\), kJ/mol

\({\rho }_{E}\), kJ/ (µm3·mol)

Experimental reference parameters (\(\eta =\) 1.1 cP; \(v=\) 0.12 µm/s; \(f=\) 1 nN; \(l=\) 2.8 µm)

3.87 × 107

1.26 × 107 (32.6%)

−2.61 × 107 (67.4%)

24.9

\(\eta\), cP

1

4.05 × 107

1.25 × 107 (30.9%)

−2.80 × 107 (69.1%)

26.0 (S1.1)

1.2

3.66 × 107

1.28 × 107 (35.0%)

−2.38 × 107 (65.0%)

23.6 (S1.2)

1.3

3.35 × 107

1.30 × 107 (38.8%)

−2.05 × 107 (61.2%)

21.8 (S1.3)

\(v\), µm/s

0.01

2.28 × 107

0.14 × 107 (6.1%)

−2.14 × 107 (93.9%)

15.1 (S2.1)

0.06

2.75 × 107

0.65 × 107 (23.6%)

−2.10 × 107 (76.4%)

17.0 (S2.2)

0.24

3.63 × 107

1.86 × 107 (51.2%)

−1.77 × 107 (48.8%)

22.7 (S2.3)

\(f\), nN

0.01

2.54 × 107

0.72 × 107 (28.4%)

−1.82 × 107 (71.6%)

16.2 (S3.1)

0.1

3.22 × 107

1.26 × 107 (39.1%)

−1.96 × 107 (60.9%)

20.6 (S3.2)

0.5

3.81 × 107

1.29 × 107 (33.9%)

−2.52 × 107 (66.1%)

24.0 (S3.3)

1.5

3.97 × 107

1.31 × 107 (33.0%)

−2.66 × 107 (67.0%)

25.5 (S3.4)

\(l\), µm

1

2.90 × 107

1.04 × 107 (35.9%)

−1.86 × 107 (64.1%)

18.8 (S4.1)

2.1

3.40 × 107

1.21 × 107 (35.6%)

−2.19 × 107 (64.4%)

21.7 (S4.2)

3.5

4.15 × 107

1.30 × 107 (31.3%)

−2.85 × 107 (68.7%)

25.9 (S4.3)

5

4.67 × 107

1.40 × 107 (30.0%)

−3.27 × 107 (70.0%)

28.9 (S4.4)

  1. Listed for different values of serum viscosity \(\eta\), filopodia extension-retraction speed \(v\), filopodia traction force \(f\), and filopodia length \(l\) are changes in the free energy change \(\Delta E\), internal energy \(\Delta U\), and entropy \(T\Delta S\) for 37 °C temperature associated with the fibrin clot contraction. Also shown are the values of energy density \({\rho }_{E}=\frac{\Delta E}{\Delta V}\) for the fibrin clot contraction. The values of \(\Delta E\), \(\Delta U\) and \(T\Delta S\), and \({\rho }_{E}\) and \(\gamma\), which correspond to the kinetic curve simulated using experimental reference parameters (Supplementary Table 1 and Fig. 4a), are shown in the first row; \(\Delta U\) and \(T\Delta S\) are also expressed in per cent of \(\Delta E\) (in parentheses). Symbols in parenthesis in the last column are denotations for data points presented in Fig. 9.
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