Fig. 4: Degradation of substrate proteins with tight domains. | npj Biological Physics and Mechanics

Fig. 4: Degradation of substrate proteins with tight domains.

From: Nonequilibrium chemomechanical transduction of ATP-driven protein unfolding in the 26S proteasome

Fig. 4: Degradation of substrate proteins with tight domains.The alternative text for this image may have been generated using AI.

a Degradation rates obtained from simulations (lines) and from experiments (dot symbols). b Normalization of the rates in (a) showing an overlap. The simulated degradation rate was calculated by dividing the peptide length (445 amino acids, as used in experiments28) by the simulated translocation rate. The parameters in our simulation are as listed in Table S2, except Fsub = 1.984 pN (or 0.2 kcal/(mol∙step)) for the green line without folic acid (FA), and Fsub = 6.44 pN (or 0.65 kcal/(mol∙step)) for the red line with FA. The experiment data are from ref. 28.

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