Fig. 5: Energy transduction in the ATPase motor during substrate unfolding and translocation. | npj Biological Physics and Mechanics

Fig. 5: Energy transduction in the ATPase motor during substrate unfolding and translocation.

From: Nonequilibrium chemomechanical transduction of ATP-driven protein unfolding in the 26S proteasome

Fig. 5: Energy transduction in the ATPase motor during substrate unfolding and translocation.The alternative text for this image may have been generated using AI.

a The free energy changes during the cycle of ATP hydrolysis and nucleotide exchange. The substrate translocation (b), the ATP hydrolysis rate (c), and the normalized efficiency of the ATPase motor in converting the chemical energy of ATP hydrolysis into mechanical work (d), respectively, as function of the resistance (Fsub) the motor experiences during substrate unfolding and translocation. The experiment data in (b) is from ref. 36.

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