Table 3 Type of radiotracers used to investigate FUS-mediated BBB opening safety and efficacy in preclinical studies
From: Imaging strategies to assess efficacy and safety of ultrasound-induced blood-brain barrier opening
Assessment | Animals | Radiotracers |
|---|---|---|
Neuroinflammation | Mice | |
Rats | 18F-DPA-714108 | |
BBB opening dynamic | Mice | 64Cu-AuNCs63,64,65,85, 18F-FDS58,59, 18F-FSPG60, 3-11C-AIB56 |
Rats | 18F-fluoro-L-phenylalanine-fructose55, 11C-erlotinib74, 11C-metoclopramide21 | |
Pharmacokinetic | Mice | 68Ga-bevacizumab57, 11C-topotecan60, 89Zr-mCD4733, 64Cu-AAV980, 18F-DASA-10 96, 89Zr-DFO-C459, 89Zr-CTX82 |
Rats | 18F-FDG62 | |
Non-human primate | 18F-Choline20 |
