Table 3 The top 5 most sensitive tumoroid compositions for each treatment are listed with their corresponding normalized viability values

From: Cracking the code: predicting tumor microenvironment enabled chemoresistance with machine learning in the human tumoroid models

 

Most sensitive tumoroid cellular composition for each treatment

Order of sensitivity

Overall drug response

Carboplatin drug response

Paclitaxel drug response

PACMA31 drug response

N773 drug response

SC144 drug response

5

least sensitive

Composition 19

120 OVCAR3 + 400 MSC + 400 EC + 100 U937

Composition 19

120 OVCAR3 + 400 MSC + 400 EC + 100 U937

Composition 4

120 OVCAR3 + 20 MSC + 20 EC + 20 U937

Composition 18

60 OVCAR3 + 300 MSC + 300 EC + 300 U937

Composition 19

120 OVCAR3 + 400 MSC + 400 EC + 100 U937

Composition 19

120 OVCAR3 + 400 MSC + 400 EC + 100 U937

4

Composition 8

30 OVCAR3 + 150 MSC + 150 EC + 150 U937

Composition 7

300 OVCAR3 + 60 MSC + 60 EC + 60 U937

Composition 8

30 OVCAR3 + 150 MSC + 150 EC + 150 U937

Composition 8

30 OVCAR3 + 150 MSC + 150 EC + 150 U937

Composition 8

30 OVCAR3 + 150 MSC + 150 EC + 150 U937

Composition 23

60 OVCAR3 + 500 MSC + 500 EC + 500 U937

3

Composition 2

60 OVCAR3

Composition 14

60 OVCAR3 + 400 MSC + 400 EC + 100 U937

Composition 2

60 OVCAR3

Composition 2

60 OVCAR3

Composition 2

60 OVCAR3

Composition 3

120 OVCAR3

2

Composition 1

30 OVCAR3

Composition 3

120 OVCAR3

Composition 1

30 OVCAR3

Composition 3

120 OVCAR3

Composition 3

120 OVCAR3

Composition 10

60 OVCAR3 + 500 EC

1

most sensitive

Composition 3

120 OVCAR3

Composition 1

30 OVCAR3

Composition 3

120 OVCAR3

Composition 1

30 OVCAR3

Composition 1

30 OVCAR3

Composition 20

60 OVCAR3 + 500 MSC + 500 EC

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