Fig. 4: Transcriptomic changes in psoriatic skin following treatment with IDO-Gal3 reveal decreased immune and fibrotic activity. | npj Biomedical Innovations

Fig. 4: Transcriptomic changes in psoriatic skin following treatment with IDO-Gal3 reveal decreased immune and fibrotic activity.

From: Indoleamine 2,3-dioxygenase-galectin-3 fusion protein remodels inflammatory and fibrotic programs, ameliorating imiquimod-induced psoriasis

Fig. 4: Transcriptomic changes in psoriatic skin following treatment with IDO-Gal3 reveal decreased immune and fibrotic activity.The alt text for this image may have been generated using AI.

a Volcano plot representing differentially expressed genes (DEGs) from skin of IDO-Gal3 treated psoriatic animals when compared to PBS-injected control psoriatic animals at day 14 of the model. b Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways enriched using g:GOst from 4037 down-regulated DEGs and 3827 up-regulated DEGs, respectively. Significant enrichment is identified with P-value < 0.01 after g:SCS adjustment. c Volcano plot representing DEGs associated with macrophage polarization. Genes associated with pro-inflammatory “M1”-like macrophage phenotype and tolerogenic/wound healing “M2”-like macrophage phenotype were shown. d Volcano plot representing skin fibrosis related DEGs. Key functions were indicated for the up- and down-regulated DEGs related to skin fibrosis, respectively.

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