Fig. 5: Targeted transcriptional analysis using the NanoString nCounter Mouse Immunology Panel exhibits a fine-tuning of immunity associated genes early in the treatment. | npj Biomedical Innovations

Fig. 5: Targeted transcriptional analysis using the NanoString nCounter Mouse Immunology Panel exhibits a fine-tuning of immunity associated genes early in the treatment.

From: Indoleamine 2,3-dioxygenase-galectin-3 fusion protein remodels inflammatory and fibrotic programs, ameliorating imiquimod-induced psoriasis

Fig. 5

a Volcano plot representing differentially expressed genes (DEGs) from the Immunology Panel in skin samples comparing psoriatic animals treated either with IDO-Gal3 or PBS (control) at day 7. b KEGG pathways (8 down-regulated, 1 up-regulated) enriched using g:GOst from 27 down-regulated DEGs and 33 up-regulated DEGs from the Immunology Panel, respectively. Significant enrichment is identified with P-value adjusted by g:SCS (Padj) < 0.01. c Heatmap representing differential expression of the genes significantly changed in both the transcriptome survey at day 14 and the targeted NanoString analysis at day 7 of the model.

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