Table 3 JNJ-2901 resistance mutations

From: Structural and mechanistic study of a novel inhibitor analogue of M. tuberculosis cytochrome bc1:aa3

Subunit

Mutation in Mtb

M. smegmatis residue

Mutant protein

QcrB

A317V

A312

A312V

QcrB

M342T

M337

M337V

QcrA

L356W

L349

L349W

  1. List of mutations in Mtb H37Rv-ΔcydAB that give rise to resistance against JNJ-2901.
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