Fig. 4: The drugged GPCRome.
a GPCRome wheel showing targeting status of all non-odorant GPCRs, which are grouped by class across concentric layers. Each receptor is color-coded according to the highest clinical phase of all agents/drugs targeting it. Untargeted GPCRs are subdivided into disease associated or no/weak disease association whether they have or not at least one disease with association score (from OpenTargets) equal or higher than 0.5. Sensory receptors are colored in green. b Tree showing the distribution across classes and receptor families of 151 GPCRs targeted by approved drugs (121) or agents in clinical trials (30). Each receptor is depicted with up to four external circles, representing the number of agents/drugs in phase I – IV, from the innermost to the outermost circle, where data is available. The circles are color-coded based on two different gradients, one based on the number of agents in clinical trials (phase I – III) and another one based on approved drugs (phase IV).
