Fig. 3: AT-02 specifically binds hypersulfated and heparan sulfate glycosaminoglycans.
From: The antibody-peptide fusion protein, AT-02, is an effective opsonin with pan-amyloid reactivity
A Binding of biotinylated AT-02 to a glycosaminoglycan array. B Binding of biotinylated AT-02 or VH9/VL4 to a heparan sulfate array. C Correlation analysis of biotinylated AT-02 binding and the total charge on glycosaminoglycan (left) or heparan sulfates (right). D Correlation analysis of the binding of biotinylated AT-02 and AT-01 to glycosaminoglycan or heparan sulfate charge (E). Correlations were performed using two-tailed Pearson analysis (rP) with α = 0.05.
