Fig. 1: EGT710 is a non-peptidomimetic reversible covalent Mpro inhibitor with potent cellular activity against SARS-CoV-2 and other coronaviruses. | npj Drug Discovery

Fig. 1: EGT710 is a non-peptidomimetic reversible covalent Mpro inhibitor with potent cellular activity against SARS-CoV-2 and other coronaviruses.

From: Preclinical characterization of EGT710, an oral non-peptidomimetic reversible covalent SARS-CoV-2 main protease inhibitor

Fig. 1

A, B Co-crystal structure of EGT710 bound to SARS-CoV-2 Mpro (PDB 9OIX) with A surface representation and B non-surface representation. C Chemical structure of EGT710. D Surface plasmon resonance sensorgrams of EGT710 interaction with his-tagged SARS-CoV-2 Mpro. E–G Cellular activity of EGT710 against E SARS-CoV-2 in different cell lines, F different SARS-CoV-2 variants, and G other alpha- and beta- coronaviruses. Figures generated using PyMol and GraphPad Prism software.

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