Fig. 4: Histological Assessment of JK07-Mediated Myocardial Remodeling. | npj Drug Discovery

Fig. 4: Histological Assessment of JK07-Mediated Myocardial Remodeling.

From: Preferential HER4 stimulation preserves neuregulin-induced improvement of myocardial function

Fig. 4: Histological Assessment of JK07-Mediated Myocardial Remodeling.

A–F Fig. 4. Histopathological changes in cardiac muscle structure induced by JK07 in rats with systolic heart failure. Cardiac tissues were collected and fixed in 4% formaldehyde, paraffin sections were then prepared and stained with H&E. A Sham control; B Vehicle control; C gp120/NRG-1 (10 mg/kg); D JK07 (1 mg/kg); E JK07 (3 mg/kg); F JK07 (10 mg/kg).

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