Table 4 Effect of JK07 on myocardial collagen type I/III expression (Mean ± SD)

From: Preferential HER4 stimulation preserves neuregulin-induced improvement of myocardial function

Group

Collagen I (%)

Collagen III (%)

Collagen I/III Ratio

Sham Control

0.9 ± 0.29

1.18 ± 0.24

0.78 ± 0.28

Vehicle Control

10.09 ± 2.18△△△

5.44 ± 1.1△△△

1.91 ± 0.52△△△

JK07 (1 mg/kg)

9.42 ± 0.81

5.5 ± 1.56

1.82 ± 0.48

JK07 (3 mg/kg)

6.35 ± 3.25*

5.15 ± 2.39

1.13 ± 0.29*

JK07 (10 mg/kg)

6.00 ± 1.22**

5.13 ± 1.95

1.21 ± 0.23*

gp120-NRG1 Fusion

6.41 ± 0.14**

5.43 ± 1.19

1.22 ± 0.29*

  1. Note: 1. △△△p < 0.01 denotes statistical significance in comparison to the sham control.
  2. 2. *p < 0.05, **p < 0.01 denotes statistical significance in comparison to the vehicle control
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