Table 3 Cognitive assessments
DOMAIN | TEST | BASELINE MEDIAN (IQR) | POST-TREATMENT MEDIAN (IQR) | P-value |
|---|---|---|---|---|
Global | MMSE | 27 (25, 29) | 25 (23, 28) | 0.06 |
AD composite | PACC-5 (Z-score) | −1.59 (−2, −0.59) | −1.59 (−2, −1.2) | 0.07 |
Attention & working memory | Digits Forward | 6 (5, 7) | 6 (5, 7) | 0.8 |
Digits Backward | 4 (4, 5) | 4 (4, 5) | 0.2 | |
Verbal list learning | HVLT Learning | 15 (14, 18) | 16 (13, 21) | >0.9 |
HVLT Recall | 0 (0, 4) | 0 (0, 4) | >0.9 | |
HVLT Disc | 6 (2, 9) | 6 (3, 9) | >0.9 | |
Visual learning | BVMT Learning | 9 (5, 11) | 8.5 (6, 10) | 0.8 |
BVMT Recall | 2 (0, 3) | 2 (1, 3) | 0.8 | |
BVMT Disc | 4 (3, 5) | 4 (3, 5) | 0.4 | |
Story memory | Logical Memory I | 22 (18, 25) | 18 (16, 24) | 0.3 |
Logical Memory II | 6 (2, 9) | 4 (0, 8) | 0.8 | |
Logical Memory Rec | 16 (14, 18) | 16 (14, 16) | 0.3 | |
Episodic memory | FCSRT Delay Free | 2 (0, 6) | 2 (0, 6) | 0.7 |
FCSRT Delay Cued | 9 (6, 10) | 10 (8, 11) | 0.8 | |
Naming | BNT | 29 (28, 29) | 29 (27, 30) | 0.4 |
Verbal fluency | Animal Naming | 14 (13, 17) | 15 (13, 17) | 0.4 |
Supermarket | 20 (16, 26) | 19 (16, 22) | 0.11 | |
S Words | 11 (10, 14) | 11 (10, 13) | 0.7 | |
P Words | 12 (9, 13) | 12 (10, 14) | 0.08 | |
Executive functioning | Trails A Time | 44 (38, 64) | 49 (32, 56) | 0.7 |
Trails B Time | 114 (94, 205) | 105 (92, 280) | 0.4 | |
Digit-Symbol Coding | 46 (34, 49) | 39 (37, 47) | >0.9 |
