Table 1 Case demographics, cognitive status and neuropathologic outcomes

From: Multiplex digital spatial profiling identifies subregion dependent targeted proteome changes across variants of dementia

 

AD

N = 6

C9orf72

N = 6

MAPT (FTLD-Tau) N = 6

FTLD-TDP

N = 6

FTLD-GRN

N = 6

NHC

N = 6

Sex, Female/Male

3/3

3/3

4/2

3/3

3/3

2/4

Average age at death, years

Average \(\pm\) SD

Median (IQR)

63.3 \(\pm\) 4.8

63 (3.5)

66 \(\pm\) 4.8

66.5 (3.25)

58.3 \(\pm\) 9.7

62 (7.75)

63.7 \(\pm\) 4.6

62.5 (6)

63.3 \(\pm\) 3.8

62 (1.5)

63.3 \(\pm\) 3.9

62.5 (3.75)

Disease duration, years

Average \(\pm\) SD

Median (IQR)

9.6 \(\pm\) 3.4

9 (4.25)

7.9 \(\pm\) 4.5

9 (4.5)

6.1 \(\pm\) 2

5 (4.5)

1 case not reported

5.5 \(\pm\) 3.3

6.5 (4.75)

6.2 \(\pm\) 2.0

6 (1.125)

n.a.

Reported race/ethnicity

5 white

1 black

6 white

6 white

6 white

1 other

5 white

2 white

4 black

ABC Score

Average \(\pm\) SD

Median (IQR)

3 \(\pm\) 0

3 (0)

0.6 \(\pm\) 0.5

1 (1)

1 case not reported

0

0 (0)

3 cases not reported

0.7 \(\pm\) 0.8

0.5 (1)

0.7 \(\pm\) 0.5

1 (0.75)

1 \(\pm\) 1

1 (0.75)

CERAD Score

Average \(\pm\) SD

Median (IQR)

3 \(\pm\) 0

3 (0)

0

0 (0)

0.7 \(\pm\) 1

0 (1.5)

0.5 \(\pm\) 1

0 (0)

0

0 (0)

0.5 \(\pm\) 1

0 (0)

ThaI Amyloid Score

Average \(\pm\) SD

Median (IQR)

5 \(\pm\) 0

5 (0)

0.8 \(\pm\) 0.8

1 (0.75)

1 \(\pm\) 2

0.5 (2.5)

1 \(\pm\) 2

0.5 (1)

1 \(\pm\) 1

1.5 (1.75)

2\(\,\pm\) 2

1.5 (1.75)

  1. ABC (Amyloid/Braak/CERAD) Score: score reflecting the degree of AD neuropathologic change (0 = none, 1 = low, 2 = intermediate, 3 = high)38.
  2. CERAD Score: Consortium to Establish a Registry for Alzheimer’s Disease score reflecting the frequency of neuritic plaques in the neocortex (0 = none, 1 = sparse, 2 = moderate, 3 = frequent)44.
  3. ThaI Amyloid Score: score reflecting the distribution of immunopositive amyloid deposits throughout the brain ranges from 0=no deposits through 5=deposits throughout the brain, including the cerebellum)45.
  4. AD Alzheimer’s disease, C9orf72 chromosome 9 open reading frame 72, MAPT microtubule associated protein tau, FTLD frontotemporal lobar degeneration, TDP = TAR DNA-binding protein 43, GRN granulin precursor, NHC neurologically healthy control, IQR Interquartile range.
Back to article page