Table 1 Demographic and disease characteristics of the cohort used for analyses
From: Heritability and shared environmental effects of brain diseases in 12,040 extended families
Subjects | ||||
|---|---|---|---|---|
Total: Final analysis cohort | 101,379 (100) | |||
Female | 53,958 (53) | |||
Age alivea, mean ± SD | 57.6 ± 20 | |||
Diedb | 51,296 (51) | |||
Died under 5 years old | 6280 (6) | |||
Died 5 years and older | 44,555 (44) | |||
Age at death (5 + )c, mean ± SD | 76.7 ± 15 | |||
Brain diseases | N cases (%) | N families (%) | Age at onset (mean ± SD) | Range in onset, years |
Alzheimer’s disease | 8149 (8) | 5195 (43) | 77.0 ± 8.8 | [38–101] |
Vascular dementia | 2040 (2) | 1764 (15) | 78.2 ± 8.2 | [40–100] |
Frontotemporal dementia | 244 (0.2) | 218 (1.8) | 71.3 ± 11 | [40–92] |
Lewy Body dementia | 192 (0.2) | 189 (1.6) | 75.7 ± 8.6 | [47–97] |
Ischemic CVA | 2436 (2) | 1977 (16) | 68.6 ± 13.9 | [10–100] |
Hemorrhagic CVA | 2165 (2) | 1765 (15) | 69.1 ± 15 | [11–104] |
Parkinson’s disease | 1091 (1) | 985 (8.2) | 67.8 ± 11 | [25–95] |
Multiple sclerosis | 223 (0.2) | 203 (1.7) | 37.7 ± 11.7 | [8–67] |
Amyotrophic lateral sclerosis | 71 (0.1) | 67 (0.6) | 63.8 ± 11.3 | [32–85] |
